Once the diagnosis of restless leg syndrome has been made, the prognosis is good and it makes sense to follow your doctor's orders. Unfortunately, there's nothing one could really do to prevent it. It's largely genetic and associated with some underlying problems. Hopefully if we can treat the underlying problems, the disease will remit on its own. Sometimes has an unusual course. It can get better. It can get worse through the life cycle, but overall it has an excellent prognosis and can be treated.